Director, Drug Metabolism

职位描述

The primary responsibility of this position is to design and conduct or monitor experiments to understand the metabolism and drug-drug interaction (DDI) properties of drug candidates, particularly the quantitative roles of enzymes in the disposition of those drug candidates (metabolic phenotyping). More broadly, the scientist is expected to integrate this information with absorption, distribution and excretion data for these compounds for a full understanding of their drug metabolism and pharmacokinetic (PK) behavior. This will include representation of the department on multidisciplinary project teams. Supervision and mentoring of other scientists and/or laboratory staff will be required. This role will be based in our headquarters in Foster City, CA.

Essential Duties and Job Responsibilities:

• Through guidance of other staff and external resources, and through direct laboratory work conduct studies to determine the kinetics of metabolism of drug candidates and to determine the roles of various enzymes in the metabolic profiles of those compounds.

• Serve as a drug metabolism and enzyme kinetics subject matter expert for multiple dynamic cross-functional teams, to define strategies to achieve target product profiles, integrate in vitro and in vivo drug disposition data, interpretation, and give presentations to teams.

• Work closely with internal and external resources to assure timely delivery of high-quality data.

• Provide clear verbal communication of results and strategies at group, department, project team and management level. Write research reports and regulatory documents.

• Contribute to science through conference presentations and publication of new findings.

Basic Qualifications:

Bachelor's Degree and Twelve Years’ Experience

OR

Masters' Degree and Ten Years’ Experience

OR

PhD and Eight Years’ Experience

Preferred Qualifications:

• A highly motivated individual with PhD degree in life sciences with 8 - 10 years of post-doctoral and/or industry experience directly related to the Specific Responsibilities listed above (hands-on experience and deep knowledge of enzymology and enzyme kinetics).

• A significant advantage would be hands-on experience in application of the enzymology data in physiologically-based PK (PBPK) modeling (using e.g. Simcyp, GastroPlus or custom models)

• Demonstrates excellent scientific verbal and technical communication, and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skills.

• Expertise and experience in one or more of the following areas:

  • Experience in drug development, authoring documents for regulatory authorities

  • Deep understanding of the principles, theories and approaches of PK, drug disposition and drug interactions. Proven application of modeling methods for quantitative translation using Simcyp, GastroPlus and/or general kinetic modeling programs.

  • State of the art bioanalysis by LC/MS and related techniques

People Leader Accountabilities

• Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams.

• Develop Talent - understand the skills, experience, aspirations, and potential of their employees and coach them on current performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop, and realize their purpose.

• Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem.