Postdoctoral Scientist, Structural Biology

职位描述

The Structural Biology Group at Gilead Sciences is seeking a highly motivated postdoctoral scientist to join our team in Foster City. The Structural Biology Group has a modern X-ray crystallography lab with high throughput crystallization robotics and frequent access to major synchrotrons, and hosts a recently established state-of-the-art cryo-EM facility with in-house Glacios and Krios G4 microscopes supported by high performance and high capacity computational infrastructure. The Structural Biology group collaborates closely with other functions such as Computational Modeling, Research Informatics, Medicinal Chemistry and Protein Therapeutics, to provide timely and enabling structural information to support diverse research projects spanning therapeutic areas such as virology, oncology, and inflammation.

This postdoc scientist will be utilizing protein biochemistry, biophysics, and structural biology techniques to elucidate the molecular mechanism of important drug targets including both small molecule and biologics programs. As part of the training, the candidate will also contribute to new cryo-EM methods development and implementation.

The successful candidate is expected to have a solid training in single particle cryo-EM and strong scientific experience as evidenced by first-author publications in top-tier scientific journals. The candidate should demonstrate excellent presentation (written & oral), collaboration and interpersonal skills.

Responsibilities:

• Construct design, protein expression and purification for structural studies.

• Cryo-EM sample preparation & optimization, data collection and structure determination of target complexes.

Basic Qualifications:

• Ph.D in structural biology, biochemistry, or a related field.

Preferred Qualifications:

• Experience in laboratory techniques supporting structural biology and recombinant protein purification, membrane protein experience is highly desirable.

• Strong communication and interpersonal skills, and the ability to work flexibly in a dynamic and collaborative environment.

• Demonstrated a strong track record of independent critical thinking and scientific achievement in research, exemplified by publications in highly regarded journals, conference presentations or generation of intellectual property.