Executive Director, Toxicologic Pathologist

Descrizione del lavoro

Gilead’s Pathology group provides intellectual and experimental input across all of R&D to enhance discovery, translational research and nonclinical safety activities. These include target identification/validation, biomarker development and implementation, and safety assessment. The team includes pathologists and scientists, and partners closely with other groups within Gilead plus an extensive network of external CROs and experts.

We are seeking an enthusiastic toxicologic pathologist with pharmaceutical/biotech experience to lead our toxicologic pathology function. Candidates should have a strong track record in partnering with scientific colleagues to identify and solve critical questions related to issues in drug discovery and development. The pathologist will work closely with our project toxicologists to design studies, interpret data and make decisions related to nonclinical safety projects and risk assessments. The role will involve peer review of non-GLP and GLP studies, plus extensive interactions with project teams and CROs. The pathologist will be a pivotal expert resource and provide guidance for toxicologic pathology input across the R&D portfolio. An ability to operate in a matrix-style environment is essential.

The pathologist will be strongly encouraged to be involved with the other major functions, including translational/biomarker science and research pathology. Experience in these other areas is highly desirable, consistent with our strategy to utilize pathobiology knowledge and input across the full spectrum of R&D. The Pathobiology group includes a highly innovative and experienced scientific team with excellent skills and advanced technological capabilities (IHC, C/FISH, multiplexing, TMAs, image analysis etc.). Pathologists work closely with this team, assisting with assay planning, development and interpretation.

Basic Qualifications:

• PhD/DVM/MD degree with 14+ years of experience in toxicologic pathology in a pharmaceutical R&D environment OR

• MA / MS degree with 14+ years of experience in toxicologic pathology in a pharmaceutical R&D environment OR

• BS / BA degree with 16+ years of experience in toxicologic pathology in a pharmaceutical R&D environment

Preferred Qualifications:

• DVM or MD, with a PhD in a relevant biological discipline.

• Board certification in anatomic pathology.

• Experience with both small molecule modalities and biologics.

• At least 20 years’ experience in toxicologic pathology in a pharmaceutical R&D environment, including screening, IND-enabling and development studies in rodent and non-rodent species.

• High level of understanding of the drug discovery, development and regulatory process, including experience working directly on drug development project teams and Regulatory Authority interactions and submissions.

• Demonstrated innovative, flexible and critical thinking applied to R&D pathobiology.

• Excellent team-working and communication skills. Able to project opinions and knowledge with confidence, authority, respect and diplomacy when interacting with all levels of Gilead colleagues and external partners.

• Excellent leadership and delegation skills demonstrated by successfully mentoring and motivating people in a matrix and/or line organization.

• Working knowledge of modern pathology laboratory technologies, including assay development, application and interpretation.

• Experience of translational/clinical biomarker and/or research pathology in a pharmaceutical R&D environment.

• Experience of molecular pathology assay development (IHC, ISH, RNASeq, qPCR, LCM), data integration and analysis, image analysis and interpretation.