Sr Director, Protein Biochemistry and Lab Automation

Descrizione del lavoro

Essential Duties and Job Functions:

• As a member of the Protein Therapeutics leadership team, set vision and develop short- and long-term strategies for new research capabilities and expanded capacity through implementation of integrated informatics and automation solutions
• Scope, design, build, and implement high-throughput and automated molecular biology and protein sciences workflows with hardware and software engineers to integrate both commercially sourced and internally built solutions
• Lead the Protein Biochemistry team to develop and execute target recombinant DNA and protein expression, purification and characterization strategies to ensure delivery of fully qualified proteins that positively impact Research projects
• Advise and provide protein reagents to enable small and large molecule lead identification and optimization campaigns, screening assay cascades, structural biology studies. Supply critical reagents to Development and CMC functions.
• Oversee externalized activities at CROs, including protocol transfer, production outsourcing, and quality control of protein samples for drug discovery programs
• Build strong partnership and timely communicate with transparency and credibility to both internal and external partners to support Gilead project portfolio
• Partner with IT and Informatics to streamline structured data capture for analytics and data sciences
• Lead both PhD and non-PhD scientists and manage people managers
• Maintain compliance with company policies and record keeping

Knowledge, Experience and Skills:

• Basic qualifications: 10+ years with Ph.D. in biochemistry, molecular and cell biology, structural biology, or equivalent degrees in a highly related discipline
• Preferred qualifications: 14+ years with Ph.D. and postdoctoral trainings and significant industry experience in biochemistry, molecular and cell biology, structural biology, or equivalent degrees in a highly related discipline
• Subject matter expertise in recombinant protein generation by bacterial and insect cells for multiple protein classes (e.g., intracellular, membrane, transcription factors and protein complexes) is a must
• Must have proven track records in designing, building and managing high-throughput automation systems integrating both commercially sourced and internally built hardware and software solutions
• Proficiency in antibody discovery, biologics engineering and developability assessment in an industry setting is highly desirable
• Ability to effectively work on multiple projects and associated campaign activities in a fast-paced matrixed environment and thrive in a fast paced, data-driven, and scientifically rigorous environment
• Must be team-oriented, motivated, and results focused with attention to details and scientific rigor
• Identify and regularly monitor team key performance indicators to build, refine, and refresh team capabilities and capacity
• Experience in small or large molecules project team leader or core team member roles is a strong plus