Scientist, Biology

Descripción del trabajo

Job Description

At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers.

We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come.

Position Overview:

We are seeking a highly motivated and creative Research Scientist to join the Discovery Sciences and Technologies (DST) Department and contribute to our biophysics capabilities to enable the identification and nomination of small molecule and biologics drug candidates across all therapeutic areas at Gilead.

DST Department members are responsible for the design and execution of rigorous, quantitative, in vitro biochemical, biophysical, and functional cellular assays. They collaborate within multi-disciplinary teams to discover and evolve drug candidates from lead identification efforts during project inception to the characterization of the final development candidate. The successful candidate will be an integral member of the DST research team and work closely with various Research functions such as medicinal chemistry, structural biology, and protein therapeutics to advance transformational therapies into clinical development for patients. Gilead is a highly matrixed organization and the ability to work effectively across diverse functional groups and therapeutic areas is a key attribute for this role.

Specific Responsibilities:

• Apply steady-state and pre-steady-state kinetic assays to characterize enzyme targets and inhibitor mechanism of action

• Experience with mass spectrometry-based and biosensor approaches for lead ID characterization of novel and traditional drug modalities including PROTACs, molecular glues and covalent inhibitors

• Strong technical background in cellular assay development and signaling pathways

• Must be both a critical and creative thinker and be able to apply an advanced level of understanding and analytical skills to interpret data and draw conclusions within the broader context of project goals

• Able to troubleshoot and optimize assays as needed, identifying, and applying novel techniques or proactively seeking out solutions

• Perform critical experiments to enable hit identification and lead optimization across therapeutic modalities

• Provide scientific insight and in-depth data interpretation to inform decision making at the project team and leadership levels

• Evaluate and implement new technologies to support advancement of internal programs and core group functions

• Contribute to several projects at any given time, work successfully in a cross-functional team environment, and communicate clearly both verbally and in writing to a variety of audiences

Basic Qualifications:

• Bachelor's Degree and 6 years experience

OR

• Master's Degree and 4 years experience

OR

• PhD /PharmD

Preferred Qualifications:

• Ph.D. with a minimum of 2 years of experience, or an M.Sc. with 5-7 years of experience in in biochemistry, enzymology, biophysics or a related scientific discipline and direct experience in assay development and/or inhibitor mechanism of action studies.

• Background in classical enzymology and biophysics (SPR ITC, MST, KinExA), including steady-state and pre-steady-state kinetics, thermodynamics, and reaction mechanism

• Expertise in a broad range of assay formats including activity assays, competitive binding assays, and direct binding assays to identify and characterize small molecules and biologics.

• Practical experience applying mass spec approaches for drug discovery and experience studying covalent and degrader small molecule modalities would be advantageous.

• Strong analytical skills and a solid understanding of rate equations and data fitting statistics

• Excellent verbal and written communication skills to disseminate information to direct colleagues and broad audiences

• Track record of productivity in diverse work environments

• The candidate should be able to think critically and creatively across multiple disciplines and have demonstrated the ability to answer complex scientific questions using a variety of biophysical techniques e.g. mass spectrometry

• Experience with automation is a definite plus

• Must be detail-orientated and extremely well-organized

• Strong interpersonal and communication skills, with enthusiasm for working in a driven environment characterized by rigorous scientific and innovative thinking

• Excellent written and oral organizational skills

People Leader Accountabilities:

• Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams.

• Develop Talent - understand the skills, experience, aspirations and potential of their employees and coach them on current performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop and realize their purpose.

• Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem.