Intern - Process Development - Analytical Development, Attribute Sciences

Arbeitsbeschreibung

As a Kite/Gilead intern you will contribute to high-impact meaningful projects that will not only further advance our company’s mission but will allow you to gain real world experience at one of the most innovative organizations in the world. You will also have opportunities to participate in special events including professional development and leadership presentations, social/network building activities and local community volunteer programs.

Key Responsibilities will include, but are not limited to the following:

The Intern will contribute to the characterization and understanding of our cell therapy products and processes through advanced analytical techniques. Specific responsibilities may include:

• Method Development: Develop and optimize LC-MS/MS methods for in-depth quantitative and qualitative proteomic analysis of cell therapy products.

• Sample Preparation: Perform complex sample preparation, including cell lysis, protein extraction, digestion, and peptide fractionation.

• Data Acquisition: Operate and maintain state-of-the-art high-resolution mass spectrometers (e.g., Orbitrap-based systems).

• Bioinformatic Analysis: Utilize bioinformatics tools and pipelines (e.g., MaxQuant, Proteome Discoverer, R, Python) for large-scale proteomics data analysis, including statistical evaluation, protein identification, quantification, and pathway analysis.

• Tool Development: Design, develop, and implement in-house bioinformatic tools and databases to enhance the storage, processing, and visualization of proprietary proteomics data.

• Collaboration & Presentation: Work cross-functionally with process development, research, and manufacturing teams, and clearly present data and conclusions to a diverse scientific audience.

• Documentation: Maintain detailed records of experiments, methods, and results.

• Showcase your work with a final presentation (PPT) near the conclusion of your internship

Required Qualifications:

• Must be at least 18 years old

• Must have a minimum GPA of 2.8

• Authorized to work in the United States without Sponsorship now or in the future or CPT/OPT through your University.

• Must be currently enrolled as a full-time student in a PhD program at an accredited US based university or college

• Must be a Graduate or Doctoral Student

• Must be enrolled full-time in the Fall Semester at an accredited university/college after the completion of the internship

• Must be able to complete a 10-12 consecutive week internship between May and August

• Must be able to relocate if necessary and work at the designated site for the duration of the internship

Preferred Qualifications:

• Ph.D/PharmD

• Proficiency with MS Office Suite

• Ability to identify issues and seek solutions

• Ability to work both independently and collaboratively

• Demonstrated commitment to inclusion and diversity in the workplace

• Efficient, organized, and able to handle short timelines in a fast-paced environment

• Currently enrolled in a PhD program in Analytical Chemistry, Biochemistry, Bioinformatics , or a closely related field.

• Extensive hands-on experience with LC-MS based proteomics workflows, including sample preparation, chromatography, and mass spectrometry data acquisition.

• Demonstrated proficiency in bioinformatic analysis of proteomics data (e.g., DDA/DIA analysis, label-free quantification, and post-translational modification analysis).

• Strong programming/scripting skills (e.g., R, Python) for data processing and visualization.

• Excellent written and verbal communication skills.

• Experience in the proteomics analysis of cellular/mammalian samples.

• Expertise in glycan database development

• Familiarity with the challenges and requirements of the biotechnology or pharmaceutical industry.

• Knowledge of protein structure, function, and post-translational modifications (PTMs).

Gilead Core Values:

• Integrity (Doing What’s Right)

• Inclusion (Encouraging Diversity)

• Teamwork (Working Together)

• Excellence (Being Your Best)

• Accountability (Taking Personal Responsibility)