Senior Associate Scientist, Clinical Pharmacology and Translational Medicine

Descripción del trabajo

For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.

We’re here for one reason and one reason only – to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We’ve made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But we're not finished yet.

Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows.

Job Description

The Senior Associate Scientist will support the Translational Medicine Pharmacodynamic Analysis team and laboratory operational activities. As a member of the Clinical Pharmacology - Translational Medicine team, you will be at the intersection of Research and Clinical Development, providing valuable insight into the function of CAR T cells in patients. This role will further involve close collaboration with Clinical and Biomarker Operational teams on patient sample tracking and data quality control.

Job Responsibilities

• Conduct clinical trial biospecimen analysis and data acquisition using multiple immunoassay platforms (i.e. ELISA, MSD, Luminex, Simple Plex Ella)
• Troubleshoot technical issues and recommend potential corrective actions
• Perform analytical instrument and software validation activities in a GxP setting
• Assist Clinical Pharmacology Scientists in identifying and reconciling biospecimen inventory
• Write, review, and edit technical documents including SOPs, development/qualification protocols and reports
• Data preparation for safety and regulatory review
• Develop analysis templates and protocols in a LIMS system
• Track biospecimen analysis needs and sample inventory using laboratory information management systems (LIMS)
• Support the transfer of methods internally and to contract-testing labs
• Develop, qualify, and deploy novel assays for immune biomarker/ cytokine monitoring
• Guide the selection and implementation of new assay technology capabilities
• Comparative data analysis with complimentary pharmacodynamic measurements (ddPCR, flow cytometry)

Basic Qualifications

Master’s and 3+ years of scientific experience

OR

Bachelor’s and 5+ years of scientific experience

OR

High School Diploma/GED and 9+ years of scientific experience

Preferred Qualifications

• Degree in immunology, cancer biology or a closely-related field and 4+ years of industry experience
• Hands-on proficiency with protein profiling technologies, with an emphasis on immunoassays (ELISA, Luminex, MSD, and Simple Plex Ella)
• Experience working with human clinical samples (i.e.. blood, serum, plasma, cerebral spinal fluid)
• Experience using visual data science platforms, such as Spotfire, GraphPad Prism, or Rstudio
• Experience coordinating analysis and communication with vendors/CROs
• Strong communication and record-keeping skills
• Familiarity with clinical testing in a GxP environment and/or assay validation parameters
• Knowledge of electronic record keeping or Laboratory Information Management (LIMS)
• Experience with clinical biomarker discovery and proteomics
• Familiarity in the areas of tumor biology, immunology and immuno-oncology and related technical skills (flow cytometry, molecular biology- ddPCR, qPCR, next-generation sequencing, RNAseq, cell culture, PBMC, immune cell isolation or functional T cell assays)
• Comfort and adaptability to a fast-paced, dynamic and matrixed environment

The work you do at Kite will help change how cancer is treated and ensure patients and their families have more time together. Ready to create more tomorrows with us? Hit apply.

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The salary range for this position is: $112,710.00 - $145,860.00. Kite considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.

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For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.