Quantitative Systems Pharmacology Manager

Job Description

At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV

treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers.

We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to

confronting the largest public health challenges of our day and improving the lives of patients for generations to come. As a Quantitative Systems Pharmacology Manager at Gilead you will ...

Key responsibilities:

As a Quantitative Systems Pharmacologist, your main role will be in scoping, developing and applying mechanistic disease progression and systems pharmacology models at Gilead. In this role, you will have opportunities to inform multiple aspects of the drug development process including optimizing drug candidates through mechanistic simulation, dose/target optimization, identifying biomarkers for clinical programs, and recommending doses, regimens and subpopulations for inclusion into clinical trial design. Further areas of focus include reverse translation of clinical findings and development of platform models to support combinations and inform portfolio development strategy.

Responsibilities

• Develop QSP models for one or more disease areas incorporating available in-house and published data

• Regularly communicate with cross-functional teams to develop and periodically update modeling strategy to ensure timely and impactful execution of modeling goals

• Present model findings to clinical teams and incorporate feedback as needed

• Provide expert guidance across teams as needed

• Contribute to regulatory documents using the appropriate level of documentation and reproducibility

• Maintain accurate records including data, assumptions, parameter values, model changes, etc. while developing models

• Author manuscripts describing model development and findings as needed

• Present modeling work externally at conferences and working groups

Basic qualifications:

6+ Years with BS
4+ Years with MS
0+ Years with PhD/PharmD

Preferred Experience and Skills:

• Proficiency in mathematical and computational skills needed for QSP modeling work, including but not limited to ordinary differential equations, linear algebra, statistics, optimization, and parameter inference

• Relevant education in computational/systems biology, physics, engineering, or computer science

• Proficiency in relevant software and programming languages which may include python, R, C++, Julia, or MATLAB and MATLAB SimBiology (preferred)

• Basic understanding of molecular and cellular biology including for example concepts from immunology, oncology, virology, cellular signaling, etc.

• Basic understanding of concepts of drug development

• PhD or PharmD degree in a relevant area of research

Preferred skills:

• Experience with QSP software and Bioinformatics tools for informing QSP models

• Familiarity with other modeling techniques: ABMs, PDEs, SDEs, SSA, graph theoretical methods, information theoretical methods, Boolean networks, etc.

• Familiarity with methodologies for Bayesian parameter inference

• Expert knowledge in one or more relevant disease areas (oncology, inflammation, virology)

• Machine learning and AI expertise (LLMs, classical methods for regression or classification)

• Application development experience (e.g. in MATLAB AppDesigner)

• Experience with pharmacokinetic/pharmacodynamic modeling in small molecules and biologics or other pharmacometric modeling experience

People Leader Accountabilities:

•Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the

way they manage their teams.

•Develop Talent - understand the skills, experience, aspirations and potential of their employees and coach them on current

performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop and

realize their purpose.

•Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding

them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem.