Research Scientist, Cell Biology – T cell Engineering

Descrizione del lavoro

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

 

We empower our leaders to step up, share ideas, listen, learn, and lead. We’re welcoming bright, diverse, and imaginative minds; we’re nurturing them to foster an environment of inclusion and growth where innovation is encouraged. We expect our people leaders to model that environment, and to focus on creating inclusion, developing talent, and enabling teams.

 

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. Join Gilead and help create possible, together.

Job Description

We are seeking a highly motivated individual to join us as a Scientist in our Disruptive Biology team. You will play a key role in developing innovative technology platforms for genetic engineering in primary immune cells. You will also contribute to the development of innovative manufacturing processes, and to the design of next generation cell therapies.

Responsibilities

• Design and conducting experiments: average expected time at the bench 70%
• Optimize fit-for-purpose assays and develop new assays
• Develop innovative solutions to problems
• Analyze and interpret data. Record data in the format required by Kite
• Communicate effectively research plans and results, in both oral and written form in team/cross-team meetings
• Keeping up to date with relevant scientific and technical developments
• Coordinate and prioritize tasks across multiple projects and different segments of the company

Location: Foster City

Basic Qualifications

Advanced scientific degree (i.e. MD, PharmD, PhD) OR

Master’s Degree and 6+ years of scientific experience OR

Bachelor’s Degree and 10+ years of scientific experience

Preferred Qualifications

• Education in immunology / cancer immunotherapy / cancer biology
• Experience working with and engineering human T cells: viral transduction and transfection using different strategies
• Experience in functional characterization of CAR-T: in vitro cytotoxicity, proliferation, cytokine production, cell signaling, activation, phenotype, differentiation and exhaustion
• Proficiency in cell culture aseptic technique, experience with different types of immune and tumor cell lines
• Independently design and implement experiments and develop and optimize fit-for-purpose assays
• Proficiency in multi-parameter flow and/or spectral cytometry including panel design, sample preparation and acquisition, antibody titration and data analysis
• Experience in synthetic biology
• Experience in molecular and cellular biology techniques, including but not limited to ELISA based assays, Proquantum, Luminex and ddPCR
• Demonstrated critical thinking, problem-solving skills and time-management skills. Self-motivated, inspired to learn new concept and techniques independently
• Ability to analyze, interpret data and communicate effectively research plans and results, in both oral and written form in team/cross-team meetings
• Proficiency using the following software: FACSDiva, FlowJo, GraphPad Prism, Excel, SnapGene, MSD Workbench. Proficiency with using genomic/bioinformatic databases
• Ability to coordinate tasks across multiple projects and demonstrate prioritization and planning skills. Being able to work both independently and as a team. Willing to provide support and training to team members with their projects.
• Posses work ethic to learn and grow in an exciting work environment. Flexible to changes in project priorities depending on company needs.
• High degree of accuracy and attention to details and in record keeping

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The salary range for this position is: $165,580.00 - $214,280.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.

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