Associate Scientist, Protein Engineering & Binder Optimization

Descrizione del lavoro

We’re here for one reason and one reason only – to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We’ve made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But we're not finished yet.

Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows.

Job Description

We are seeking a highly motivated and detail‑oriented Associate Scientist to join the Protein Engineering & Binder Optimization group within Kite Research. This role is primarily bench‑focused and execution‑driven, with a strong emphasis on hands‑on laboratory support for high‑throughput protein expression, purification, and analytical characterization.

The Associate Scientist will be a critical contributor to discovery and optimization programs, serving as a reliable experimental operator who enables scale, speed, and data quality across multiple protein engineering efforts. This position is well‑suited for an individual who thrives in a fast‑paced research environment, values rigor and reproducibility, and is excited to build deep technical expertise in protein production and analytics.

Key Responsibilities

High‑Throughput Protein Expression & Purification (Primary Focus)

• Execute high‑throughput cloning, expression, and purification of recombinant proteins and binders across multiple formats (e.g., bacterial, mammalian, or yeast systems, as applicable).

• Perform parallelized small‑scale and mid‑scale protein production to support binder discovery and optimization workflows.

• Prepare purified proteins for downstream applications, ensuring appropriate quality, concentration, and documentation.

• Rigorously track samples, constructs, and yields using electronic lab notebooks and sample management systems.

Protein Characterization & Analytics

• Perform routine and advanced protein analytical assays, such as SDS‑PAGE, SEC, ELISA, and concentration/quality assessments.

• Support binding and functional characterization efforts (e.g., sample preparation for SPR/BLI, cell‑based assays, or functional screens).

• Assess protein quality, stability, and suitability for downstream assays; flag issues and propose troubleshooting steps.

Experimental Execution in Discovery Programs

• Provide consistent, high‑quality experimental execution in support of binder discovery, optimization, and validation campaigns.

• Work from protocols while developing the technical judgment to recognize deviations, failures, or optimization opportunities.

• Generate clear, reproducible, and decision‑ready experimental data that feeds directly into program workflows.

Workflow Support & Continuous Improvement

• Contribute to the robustness and scalability of protein production and analytical workflows.

• Identify opportunities to improve throughput, reproducibility, or data quality through protocol refinement and standardization.

• Maintain well‑organized lab spaces, reagents, and shared resources to support efficient team operation.

Collaboration & Communication

• Collaborate closely with Scientists and computational partners within the larger Protein Science team

• Communicate experiment status, results, and issues clearly in team discussions and written records.

• Engage constructively with cross‑functional partners (e.g., Cell Biology, Translational teams) as needed for sample handoff and assay support.

Basic Qualifications

• Master’s degree with 2+ years of relevant scientific experience
  OR

• Bachelor’s degree with 4+ years of relevant scientific experience

Preferred Qualifications

• Bachelor’s or Master’s degree in Biochemistry, Molecular Biology, Protein Science, Bioengineering, or a related discipline

• Hands‑on laboratory experience in recombinant protein expression and purification

• Demonstrated ability to execute repetitive, high‑throughput wet‑lab workflows with accuracy and consistency

• Strong attention to detail and commitment to data quality and experimental traceability

• Experience with parallelized or automated protein expression/purification workflows

• Familiarity with common protein analytics and characterization methods (e.g., SEC, ELISA, biophysical assays)

• Experience working in electronic lab notebooks and sample/LIMS systems

• Prior experience supporting protein engineering, antibody, or binder discovery programs

Attributes for Success

• Highly reliable experimental executor who takes pride in high‑quality bench work

• Organized, methodical, and comfortable managing multiple samples and workflows in parallel

• Learns quickly from feedback and adapts to evolving experimental needs

• Collaborative team member who enables the productivity of Scientists and program teams

• Motivated to build deep technical expertise in protein expression, purification, and analytics within a discovery research environment

This role will report into the Protein Engineering & Binder Optimization group complementing it through strong bench‑level execution and experimental scale.

The salary range for this position is: $109,650.00 - $141,900.00. Kite considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.

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Kite Pharma is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.

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For Current Kite Pharma Employees and Contractors:

Please apply via the Internal Career Opportunities portal in Workday.