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Sr. Research Associate II, Viral Vector Downstream Process Development

United States - California - Santa MonicaProcess/Product Development & OperationsRegular

Job Description

Kite Viral Vector Downstream Process Development is seeking for highly motivated Sr. Research Associate II to join our team in Santa Monica.  The Sr. Research Associate II will be part of viral vector downstream process development team to develop and characterize Lentiviral processes supporting clinical and commercial manufacturing. As the Sr. Research Associate II, the individual will work and collaborate with Upstream, Analytical development, Formulation, Drug Product and MSAT teams to support ongoing pipeline products.  The responsibilities also include authoring technical reports, process transfer documents, process control strategy and process related documents.  The Sr. Research Associate II will also support development and implementation of innovative downstream technology platforms.

Key Responsibilities

  • Plan and execute viral vector downstream process development and characterization studies  
  • Perform normal flow and tangential flow filtration operations, chromatographic separations
  • Support process scale up and technology transfer to clinical and commercial manufacturing production sites
  • Perform routine analytical testing, process analysis and trend process performance
  • Write and review technical documentation
  • Presents results of work, interprets data, and draws conclusions regarding presented material and nature of work 
  • Act as a resource for other employees within the department
  • Maintain familiarity with scientific literature and applies appropriately to research projects
  • Demonstrate strong verbal communication skills and interpersonal skills
  • Works with collaborative communication and problem-solving spirit

Qualifications: 

  • 2+ years of experience with MS degree in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline
  • 4+ years of experience with BS degree in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline
  • 5+ years of experience with AS degree in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline
  • 6+ years of related experience in Chemical/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline and High School Diploma

Additional Skills:

  • Understand different modes of chromatographic separation and filtration principles
  • Experience with chromatography and/or filtration process design, optimization and characterization
  • Excellent communication and effective presentation and writing skill  
  • Competency designing and executing studies employing one or more of the following operating systems: ÄKTA chromatography with UNICORN software, tangential flow filtration, ultrafiltration / diafiltration, PendoTECH systems, depth filtration, normal flow membrane filtration, or sterile filtration
  • Demonstrated experience maintaining and advancing a culture of safety within work and laboratory settings
  • Demonstrated experience going above and beyond work responsibilities to lead self-motivated projects to improve technical or business processes
  • Demonstrated experience to interface with colleagues with diverse areas of expertise or experience levels to achieve team objectives
  • Some experience running molecular biology assays (ELISAs, gel electrophoresis, flow cytometry) is preferred
  • Background knowledge of in viral vector or biologics downstream process development, process technology transfer, and statistical DOE (design of experiments) is preferred but not required.