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Senior Research Associate - Analytical Development

United States - California - Santa MonicaProcess/Product Development & OperationsRegular

Descripción del trabajo

We are seeking a talented and motivated biologist with a passion for laboratory executions specializing in cell biology and multi parametric flow cytometry based immunophenotyping, analysis of the data and its organization and presentation. The successful candidate will be responsible for the handling and maintenance of associated materials such as cells and reagents in established and controlled manner to ensure successful outcomes. The successful candidate will work collaboratively as part of a team and execute flow cytometry and cell biology based experiments during analytical method development for GMP release of cell therapy products, maturation of research analytical methodology into GMP methods, and analytical method technology transfer to appropriate cross functional partners.

The SRA will be accountable to accurately document, analyze, interpret, and present experimental data in departmental meetings. They will co-author/author and assist in review of method development reports, test methods and SOPs to support release of drug substance and drug products as applicable. The successful candidate will have opportunity to grow as an expert in analytical method development and learn to eventually lead development projects independently. The SR Research Associate will work with a team to support on critical cross-functional projects to enable assay development to support the manufacturing process and drug product development of Kite's

 Responsibilities

  • Perform flow cytometry based analytical method development and qualification to enable product release of Kite’s T cell therapies
  • Conduct multicolor flow cytometry experiments to enable routine and non-routine analysis of cellular products
  • Conduct experiments by rigorously implementing approved protocols and following good documentation practices
  • Execute and document cell culture and passaging and banking activities as required
  • Plan and execute assigned experiments that support routine development activities and project goals.
  • Systematically record data and analyze the results of laboratory operations to ensure compliance to appropriate test methods, specifications, and protocols.
  • Participate in analytical method transfer activities to clinical and commercial QC and other cross functional teams  
  • Participate in meetings, present data, provide expertise in areas of responsibility and analyze and prepare data for sharing
  • Operate and troubleshoot laboratory instrumentation that is used routinely in execution of assays
  • Support testing as needed to enable process development, innovation and   investigations
  • Ensure that departmental work areas are maintained per 5S guidelines

Basic Qualifications

  • Master’s Degree and 2+ years of industry experience OR
  • Bachelor’s Degree and 4+ years of Industry experience OR
  • Associate Degree and 5+ years of Industry experience OR
  • High School Degree and 6+ years of Industry experience

Preferred Qualifications

  • Experience with multi-color flow cytometry technology and associated instrumentation
  • Knowledge and experience in flow cytometry data analysis using FACSDiva, FlowJo and other relevant software
  • Experience in cell sorting is a plus
  • Knowledge of mammalian cell culture including primary T cells
  • Proficient in the use of Microsoft Office, data analysis software (e.g. Prism, JMP) and other applications
  • Ability to think critically and demonstrate troubleshooting and problem-solving skills
  • Excellent interpersonal, verbal and written communication skills and a strong team player
  • Self-motivated, detail-oriented, and willing to accept temporary responsibilities outside of initial job description
  • Experience and aptitude in working in a multidisciplinary laboratory environment with moderate supervision
  • Comfortable in a fast-paced small company environment with minimal direction

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